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SERPINE1 in Thrombophilia SERPINE1 gene encodes plasminogen activator inhibitor type 1 (PAI-1) and inhibits fibrinolysis, or clot dissolution. The 4G variant results in increased expression of SERPINE1 and consequently higher inhibition of fibrinolysis, thus leading to thrombophilia. Below are verbatim
This is an email interview with the Founders of Swagene that will be published over two parts. Read Part I here. What are the challenges faced by your startup? R&D is quite finance-intensive. Although we work with a jugaad mentality,
This is an email interview with the Founders of Swagene that will be published over two parts. Introducing Swagene: Could you tell us something about your venture? Swagene is an expert molecular diagnostic lab that pioneers bench-to-bedside translation of advanced clinical
What is Personalized Medicine (PM) and how is this new approach enabling better healthcare? Medical practitioners have always known that patients respond differently to drugs and procedures; one of the simplest examples would be allergies, for instance to peanuts or medicines.
A novel subgroup of B-cell ALL with CD2 expression that does not belong in the other defined groups has been recently discovered26,27. This subgroup harbors intragenic deletions in the ERG gene that codes for a transcription factor in hematopoiesis. It
IKZF1 The IKZF1 gene on the short-arm of chromosome 7 codes for IKAROS, a hematopoietic transcription factor with an essential role in lymphoid differentiation. It rose to prominence in 2009 when multiple groups discovered recurrent focal deletions in its exons11,12,
DNMT3A codes for the enzyme DNA methyltransferase 3A that facilitates DNA methylation, thus playing a major role in epigenetic regulation of gene expression. In 2010, the first carcinogenic mutations in DNMT3A were identified1, which have since been found to occur
The burden of tuberculosis (TB) in India is the highest, accounting for one-fifth (21%) of the global incidence [1]. TB affecting organs other than the lungs is known as extrapulmonary TB (EPTB). The paucibacillary smear status and localization into sites
Heart Attack and Stroke Risk: Thrombophilia Blood clotting is regulated by your genes. Some people have a high propensity of clotting which can lead to high risk of developing heart attack, stroke, pulmonary embolism, or venous thrombosis. This test is
Medicine for Thrombosis and Stroke may cause the other extreme: Bleeding emergencies on Warfarin Warfarin or Coumadin is one of the most popular drugs in the world, and the leading cause of emergency hospitalizations in the USA. This is because
Heart drug may cause Heart Attack or Bleeding: Clopidogrel People with heart disease and/or stroke are put on this medicine, but in the majority it leads to heart attack, which it was intended to prevent, or to bleeding emergencies. This
Drug-induced Muscle Damage: Statins for Cholesterol and Diabetes Tablets are given to reduce cholesterol for people with high blood pressure or in diabetics. They can lead to muscle degradation leading to aches, pains and cramps of muscles, and eventually in
Blood Pressure Pills: Are you taking too much? High BP, which is also called 'the Silent Killer' is one of those conditions that is treated with more medicines than needed. This is because some of them work for you, but
For several pregnancy complications, like Preeclampsia, Repeated miscarriage or abortions, Implantation failure and Growth restriction, this test is recommended by all Professional Organizations: American Society for Reproductive Medicine Royal College of Obstetricians and Gynecologists American College of Medical Genetics British
Guiding therapy to make you a father: Y Chromosome Microdeletions test If your sperm count is between 0-5 million per ml (Azoospermia or Severe Oligozoospermia), this test is recommended by all Professional Organizations: American Society for Reproductive Medicine European Academy
Many women have inadequate hormone activity leading to cancelled cycles and IVF failure! Your genes guide your tailored IVF protocols with evidence of success in IVF and pregnancy rates over the last two decades: >30% improved pregnancy rates Lower costs
Many men have inadequate hormone activity leading to different problems in sperms that can be corrected by hormone therapy, but only in men with genetic mutations affecting hormone function. This test is for all men with: Low to normal sperm
Blood cancer, or leukemias, are complicated because of the large number of ‘driver’ genetic mutations seen in the disease. These mutations affect the disease in terms of severity, survival, and risk of relapse. Apart from detecting the disease and
...INTRO LINES... The anti-cholesterol statins can cause muscle-related side-effects (myopathy) Personalize your statin and its dosage to avoid severe conditions such as myopathy, myalgia and rhabdomyolysis 16-fold higher risk of myopathy Statin is the most commonly prescribed drug for reducing
...INTRO LINES... Beta-blockers don't control blood pressure for everyone Long-term risk of diabetes. Confirm your response before taking this life-long drug BP control and risk of diabetes 30 to 60% of hypertensive patients who are on beta-blocker monotherapy fail to
