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Heart disease can soon become very expensive, what with all the medicines every day, and annoying complications on top of that! See below how Precision medicine has saved a lot of money for a couple of patients with heart disease.
Vinay (true story, name changed) was an active politician, all of 82 years old and only 53 kg when he visited us. He had undergone heart bypass surgery 10 years ago, and like everyone else with heart disease or cardiac
Clopidogrel: Personalized medicine Clopidogrel is a platelet inhibitor used in patients with cardiovascular or cerebrovascular risk. It has a very narrow therapeutic index depending on the patient’s metabolism, which is influenced by CYP2C19. Based on the genotype, patients are classified
Diuretics: Personalized medicine Diuretics are often the first line of treatment for hypertension, but their effectiveness in terms of BP (blood pressure) lowering is inconsistent. The NEDD4L gene has a strong pharmacogenetic effect on the efficacy of thiazide diuretics. It
β-blockers: Personalized medicine 30 to 60% of hypertensive patients who are on beta-blocker monotherapy fail to respond adequately. This variation in response is accounted for by a genetic polymorphism in the ADRB1 gene, which encodes the adrenergic beta-receptor type-1 to
Warfarin: Personalized medicine Warfarin (coumarin), acenocoumarol and phenprocoumon are vitamin K antagonist (VKA) anticoagulants used in patients with deep vein thrombosis, thromboembolism, cardiovascular or cerebrovascular risk, or after surgery. It has a very narrow therapeutic index and causes severe adverse
Statins: Personalized medicine Despite the benefits of statin treatment in lowering cholesterol, statin-related adverse effects including myalgia and myopathy have been widely reported in patients. The incidence of muscle complaints in patients using statins is 9-20% in an outpatient setting.
Heart Attack and Stroke Risk: Thrombophilia Blood clotting is regulated by your genes. Some people have a high propensity of clotting which can lead to high risk of developing heart attack, stroke, pulmonary embolism, or venous thrombosis. This test is
Medicine for Thrombosis and Stroke may cause the other extreme: Bleeding emergencies on Warfarin Warfarin or Coumadin is one of the most popular drugs in the world, and the leading cause of emergency hospitalizations in the USA. This is because
Heart drug may cause Heart Attack or Bleeding: Clopidogrel People with heart disease and/or stroke are put on this medicine, but in the majority it leads to heart attack, which it was intended to prevent, or to bleeding emergencies. This
Drug-induced Muscle Damage: Statins for Cholesterol and Diabetes Tablets are given to reduce cholesterol for people with high blood pressure or in diabetics. They can lead to muscle degradation leading to aches, pains and cramps of muscles, and eventually in
Blood Pressure Pills: Are you taking too much? High BP, which is also called 'the Silent Killer' is one of those conditions that is treated with more medicines than needed. This is because some of them work for you, but
...INTRO LINES... The anti-cholesterol statins can cause muscle-related side-effects (myopathy) Personalize your statin and its dosage to avoid severe conditions such as myopathy, myalgia and rhabdomyolysis 16-fold higher risk of myopathy Statin is the most commonly prescribed drug for reducing
...INTRO LINES... Beta-blockers don't control blood pressure for everyone Long-term risk of diabetes. Confirm your response before taking this life-long drug BP control and risk of diabetes 30 to 60% of hypertensive patients who are on beta-blocker monotherapy fail to
...INTRO LINES... Thrombophilia, or hypercoagulability, is the increased tendency of blood to clot These genetic mutations can cause heart attack or stroke in the absence of conventional risk factors Cardio/Cerebrovascular disease Myocardial infarction (heart attacks) and strokes are seen in
...INTRO LINES... Precise dosing of Clopidogrel to prevent severe side-effects Individualized clopidogrel dosage helps avoid emergencies from morbid bleeding and clotting 60% of population faces high risk Formation of a blood clot in the artery to the heart or the
...INTRO LINES... Warfarin is a leading cause of emergency hospitalization Personalized warfarin dosage can help you avoid emergency bleeding and hospitalizations ...RISKS WHAT THE TEST DOES PARAGRAPH... Most common reason for emergency hospitalization Warfarin (coumarin), acenocoumarol and phenprocoumon are vitamin
...INTRO LINES... Diuretics, thiazides, may not control your blood pressure, unless you have a genetic variation determining salt-sensitive hypertension. Controlling hypertension is important to reduce risk of heart attack and stroke Controlling BP, the silent killer About 58% of the population
The right drug, at the right dose, at the right time Save your heart! Opt for personalized treatment for a healthy body and avoid severe side-effects. Clopidogrel (blood thinner) Clopidogrel is a blood thinner given to heart patients. Higher doses increase risk of
