SERPINE1 in Thrombophilia SERPINE1 gene encodes plasminogen activator inhibitor type 1 (PAI-1) and inhibits fibrinolysis, or clot dissolution. The 4G variant results in increased expression of SERPINE1 and consequently higher inhibition of fibrinolysis, thus leading to thrombophilia. Below are verbatim
This is an email interview with the Founders of Swagene that will be published over two parts. Read Part I here. What are the challenges faced by your startup? R&D is quite finance-intensive. Although we work with a jugaad mentality,
This is an email interview with the Founders of Swagene that will be published over two parts. Introducing Swagene: Could you tell us something about your venture? Swagene is an expert molecular diagnostic lab that pioneers bench-to-bedside translation of advanced clinical
What is Personalized Medicine (PM) and how is this new approach enabling better healthcare? Medical practitioners have always known that patients respond differently to drugs and procedures; one of the simplest examples would be allergies, for instance to peanuts or medicines.
A novel subgroup of B-cell ALL with CD2 expression that does not belong in the other defined groups has been recently discovered26,27. This subgroup harbors intragenic deletions in the ERG gene that codes for a transcription factor in hematopoiesis. It
IKZF1 The IKZF1 gene on the short-arm of chromosome 7 codes for IKAROS, a hematopoietic transcription factor with an essential role in lymphoid differentiation. It rose to prominence in 2009 when multiple groups discovered recurrent focal deletions in its exons11,12,
DNMT3A codes for the enzyme DNA methyltransferase 3A that facilitates DNA methylation, thus playing a major role in epigenetic regulation of gene expression. In 2010, the first carcinogenic mutations in DNMT3A were identified1, which have since been found to occur
The burden of tuberculosis (TB) in India is the highest, accounting for one-fifth (21%) of the global incidence [1]. TB affecting organs other than the lungs is known as extrapulmonary TB (EPTB). The paucibacillary smear status and localization into sites
Heart Attack and Stroke Risk: Thrombophilia Blood clotting is regulated by your genes. Some people have a high propensity of clotting which can lead to high risk of developing heart attack, stroke, pulmonary embolism, or venous thrombosis. This test is
Medicine for Thrombosis and Stroke may cause the other extreme: Bleeding emergencies on Warfarin Warfarin or Coumadin is one of the most popular drugs in the world, and the leading cause of emergency hospitalizations in the USA. This is because