Most Arthritis and Joint Pains are Genetic
HLA-B27 is an immune gene that starts fighting against the body’s own bones and joints causing a group of diseases called Spondylosing Arthropathies. These include, Spondyloarthritis, Ankylosing Spondylitis, Uveitis (in the eyes), Reactive Arthritis, Juvenile Arthritis (in the young). Testing for this gene is the only confirmatory diagnosis for the condition and a preliminary for precision diagnosis and treatment.
While there are many genes involved in other prevalent arthritic diseases such as Rheumatoid Arthritis and Osteoarthritis, researchers are still uncovering these genes and finding out how they contribute to disease. So they are not yet clinically relevant to be tested in people and patients.
Use Precision Genetics to take the Right, Safe Painkillers
The drugs used commonly in arthritis are cytotoxic, meaning their function is to kill cells. Naturally, these drugs also cause severe side-effects in many people ranging from toxicity to the liver (hepatotoxicity), to blood and circulation (hematotoxicity), to the bowels (gastrointestinal toxicity) and other organs.
Protect yourself from replacing one disease with another by first ensuring that you can safely use these drugs – this is done by genetics because genes determine the risk of severe toxicity.
Drugs include: Methotrexate, Azathioprine, Mercaptopurine, Thioguanine, Thiopurines etc.
- Do I have Spondylosing, Reactive (or) Juvenile arthritis?
- Do I have the risk gene for Uveitis and other autoimmune diseases?
- Am I susceptible to frequent bone and joint pains?
- Genes: HLA-B27
- What is my safe dose of Methotrexate?
- How can I avoid Gastrointestinal toxicity?
- How to keep my liver safe from Hepatotoxicity?
- Genes: SLCO1B1
- What is my safe dose of Thioguanine?
- Can I safely take Azathioprine?
- Are Mercaptopurines toxic to me?
- Genes: NUDT15
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