Blood thinners for Heart and Brain (Warfarin)

Medicine for Thrombosis and Stroke may cause the other extreme: Bleeding emergencies on Warfarin

Warfarin or Coumadin is one of the most popular drugs in the world, and the leading cause of emergency hospitalizations in the USA. This is because it is safe within a very narrow range, and most people end up using unsafe doses. This test is for you:

Heart attack or Stroke
Risk of Heart disease or Stroke
Clotting disease: Thrombosis, Thrombophilia
Users of Warfarin (Coumadin), or Dabigatran, Acenocoumarol, Phenprocoumon

The US FDA recommends genetic testing for guiding the safe dose of this medicine, and several studies have shown a 50-60% decrease in emergency hospitalization when given after genetic testing. If you’re taking expensive drugs that cost Rs 4000-5000 per month, let’s find out if you can take a safe dose of this cheap medicine and save thousands.

Please do not take or modify therapy without your doctor's consultation

Product Description

Click here for explanation on the science about the genetics

The most common blood thinners used in medicine have to be given at the right dose for them to be safe. Instead, if you’re taking drugs that are 100-times more expensive, you may be wasting money unnecessarily. The report will predict your risks for emergencies related to internal bleeding when given this drug and advice your doctor on the safe dosage.

On the other hand, those of you that can take this medicine safely may be taking other more expensive drugs. This test will guide you on switching to the cheaper generic medicine and staying healthy both in body and bank account.

Science

Genes tested: VKORC1, CYP2C9*2, CYP2C9*3

The vast majority of people carry genetic mutations that lead to very fast metabolism of this class of medicines. This will lead to very high concentrations of the drug in blood. Instead of protecting the body by thinning the blood, these excess concentrations lead to internal bleeding frequently being so severe that patients end up in emergency rooms.

References

Franchini M et al. 2014, Journal of Thrombosis and Haemostasis
Jin B et al. 2014, Current Medical Research Opinion
Johnson JA et al. 2011, Clinical Pharmacology and Therapeutics
Finkelman BS et al. 2011, Journal of the American College of Cardiology
Epstein RS et al. 2010, Journal of the American College of Cardiology