Many men have inadequate hormone activity leading to different problems in sperms that can be corrected by hormone therapy, but only in men with genetic mutations affecting hormone function. This test is for all men with:
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Low to normal sperm count and concentration
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Poor motility of sperms
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DNA fragmentation in sperms
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Unexplained or Idiopathic infertility
Guided by your hormone function and activity, spend less money to become a father, and instead save for your new family! These mutations are NOT identified by the routine hormone tests, and require specialized genetic tests.
The report will guide you on success with short-term hormone therapy, which studies have shown even lead to spontaneous pregnancy! You are likely to be eligible for much less invasive reproductive procedures such as the more affordable IUI (sperm insemination).
FAQ
I am positive for this test, will I benefit from FSH therapy?
Studies have shown that a vast majority of men carrying these mutations significantly benefit from a 3-month FSH course with normal sperm and fertility parameters. However, because of various factors affecting fertility, a definitive outcome cannot be predicted.
Will I still need artificial reproductive techniques?
Your doctor will advise regarding the treatment for you. ART may be indicated if the female partner is also infertile. Our female FSH panel diagnoses women undergoing IVF or ICSI for targeted treatment and improved outcome.
Will my family be affected by this mutation?
Your family and children are likely to carry these mutations. However, not all people with these mutations are infertile. It is recommended to test infertile male family members to guide personalized therapy.
Does having the mutation make me infertile?
Not necessarily. Almost 1 in 2 men have FSHR variant, and 1 in 10 have FSHB variant. Not all of them will be infertile. However, in infertile men, there is a high likelihood of these variants playing a role in infertility.
Science
Genes tested: FSHR and FSHB
Hormones are essential for normal sperm production in men. However, many men have mutations in their genes for hormones or hormone receptors that disrupt their normal function. Identifying these mutations will help predict your response to hormone therapy, thereby enabling Precision Medicine.
References
Simoni M et al. 2015, ESHRE conference
Grigorova M et al. 2014, PLoS One
Valenti D et al. 2013, Nature Reviews Urology
Grigorova M et al. 2013, Andrology
Ferlin A et al. 2011, Fertility and Sterility
Selice R et al. 2011, International Journal of Andrology