For several pregnancy complications, like Preeclampsia, Repeated miscarriage or abortions, Implantation failure and Growth restriction, this test is recommended by all Professional Organizations:
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American Society for Reproductive Medicine
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Royal College of Obstetricians and Gynecologists
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American College of Medical Genetics
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British Society for Hematology
Pregnancy is a cherishable and enjoyable physiological event in your life. Do you want to spend most of it in bed? Assess your risk for complications by this test and learn how to manage them.
The Premium test has 3 genes in the panel. The report will guide you on the risk of developing several pregnancy complications such as preeclampsia, recurrent miscarriage, abortions, implantation failure, growth restriction. Knowing the risks will allow you to be a lot more cautious and alert, and proactively manage any events that may arise in consultation with your doctor.
FAQ
What do I do in case of a positive result?
Consult your doctor or gynecologist for personalized treatment of your condition and to avoid risk during pregnancy. Further consultations and monitoring may be needed to prevent future thrombotic events.
Will my family be affected?
These mutations are hereditary and if variation(s) are reported, there are chances that family members may also be affected. It is recommended to test family members for their risk.
Am I safe if my results are negative?
Further tests may be necessary to rule out thrombophilia. These include functional assays for protein C, protein S and antithrombin, and anti-phospholipid antibody testing.
What about MTHFR mutations?
Both American College of Medical Geneticists and British Society for Haematology recommend against testing MTHFR for thrombophilia due to lack of concrete evidence. If testing is still considered, hyperhomocysteinemia may be tested.
Science
Genes tested: Factor V Leiden, Factor II Prothrombin, and PAI-1 (SERPINE1)
Up to 60% of several pregnancy complications have been attributed to a widely prevalent blood clotting disorder called Thrombophilia or Hypercoagulability. Pregnancy is an already thrombophilic condition, and having these genetic variations in addition multiplies the risks manifold, as these variations predispose an individual to an increased tendency of spontaneous blood clotting. When this happens to the placenta or affects the uterus, it leads to complications.
We do NOT advise testing for MTHFR mutations for Thrombophilia because the scientific evidence there is contradictory. It has consequently been recommended against by both American College of Medical Genetics and British Society for Hematology.
There are additional factors to test during pregnancy, and the factors here test for the most prevalent genetic contributors to Thrombophilia, that are recommended by all Professional Organizations.
References
American College of Medical Genetics 2013, (Practice Guideline in) Genetics in Medicine
American Society for Reproductive Medicine 2012, (Committee opinion in) Fertility and Sterility
Royal College of Obstetricians and Gynecologists 2011, Green-top Guideline 17
British Society for Hematology 2011, (Clinical guideline in) British Journal of Haematology
American College of Medical Genetics 2007, Consensus statement on Factor V Leiden mutation testing
British Society for Hematology 2001, (Guideline in) British Journal of Haematology